文獻(xiàn)資料
聯(lián)系我們
浙江果源康品生物科技有限公司
電話：0570－8788056
傳真：0570－8788381
地址：浙江省衢州市東港經(jīng)濟(jì)開發(fā)區(qū)
東港4路2號(hào)
- 果膠與癌癥治療綜述
- 發(fā)布時(shí)間： 2019/4/17 點(diǎn)擊次數(shù)：5531
-
果膠與癌癥治療綜述
作者：張文博，Ping Xub，Han Zhanga
a.新鄉(xiāng)醫(yī)科大學(xué)生命科學(xué)與技術(shù)學(xué)院，河南新鄉(xiāng)453003
（電話：D86 373 3831928;傳真：D86 373 3029887;
電子郵件：zhangwenbo@xxmu.edu.cn）（電子郵件：zhanghan317@163.com）
b新鄉(xiāng)醫(yī)科大學(xué)藥學(xué)院
河南新鄉(xiāng)45300（電子郵件：13273730271@163.com）
果膠是一類復(fù)雜的植物多糖，由半乳糖醛酸和中性糖側(cè)鏈組成。據(jù)報(bào)道，天然果膠可作為膳食纖維（DF）預(yù)防結(jié)腸癌。為了提高其生物利用度和生物活性，果膠被改造成生物可利用的具有低分子量的改性果膠（MPs）。此外，MPs具有低酯化度（DE），據(jù)報(bào)道它有抑制腫瘤生長(zhǎng)，誘導(dǎo)細(xì)胞凋亡，抑制轉(zhuǎn)移和調(diào)節(jié)免疫的作用。 MPs的抗腫瘤活性源于半乳糖凝集素-3（Gal-3）對(duì)配體識(shí)別的干預(yù)。此外，由于其豐富的改性功能團(tuán)和特殊的物理化學(xué)性質(zhì)，果膠是抗癌藥物遞送系統(tǒng)的合適載體。在這里，我們總結(jié)了結(jié)構(gòu)特征，生物吸收和抗腫瘤機(jī)制以及MPs的結(jié)構(gòu) - 活性關(guān)系。我們還為將果膠開發(fā)成保健品或藥物提供了前景和挑戰(zhàn)。
Pectin in cancer therapy: A review
Wenbo Zhanga,*, Ping Xub and Han Zhanga
aSchool of Life Sciences and Technology, Xinxiang Medical University, Xinxiang 453003, Henan, China
(Tel.: D86 373 3831928; fax: D86 373 3029887;
e-mail: zhangwenbo@xxmu.edu.cn)
(e-mail: zhanghan317@163.com)
School of Pharmacy, Xinxiang Medical University,
Xinxiang 453003, Henan, China
(e-mail: 13273730271@163.com)
Pectin, a complex class of plant polysaccharides, is composed of a galacturonan backbone and neutral sugar side chains. Natural pectin is reported to prevent colon cancer as a dietary fiber (DF). To enhance its bioavailability and bioactivity, pectin was modified into bioavailable modified pectin fragments(MPs) with low molecular mass. Also, MPs had low degrees of esterification (DE) which is reported to inhibit tumor growth, induce apoptosis, suppress metastasis, and modulate immuno- logical responses. Antitumor activity of MPs chiefly arises from intervention in ligand recognition by galectin-3 (Gal-3). In addition, pectin is a suitable vehicle for anti-cancer drug deliv- ery systems, due to its abundant modifiable functional groups and special physicochemical properties. Here, we summarize the structural features, bio-absorption and antitumor mecha- nisms and the structure-activity relationship of MPs. We also offer prospects and challenges for developing pectin into nu- traceuticals or drugs. - 上一篇：低分子柑橘果膠聯(lián)和臨床常用化療藥用于控制癌癥和癌癥轉(zhuǎn)移擴(kuò)散
下一篇：Galectin-3抑制神經(jīng)性疼痛周圍神經(jīng)損傷后衰減 - 返回新聞列表
