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高溫度－和處理ph值－改性柑橘果膠抗腫瘤作用比較研究

 《食品&功能》，2013，4，960-971

摘要

通過(guò)高溫和PH處理柑橘果膠獲得低分子量改性果膠。本實(shí)驗(yàn)比較了高溫改性果膠（HTCP）和PH改性果膠（MCP）對(duì)于8種腫瘤細(xì)胞以及S-180腫瘤模型小鼠的效果。實(shí)驗(yàn)結(jié)果表明，HTCP能抑制腫瘤細(xì)胞增生，誘導(dǎo)caspase-3依賴性的細(xì)胞凋亡和G2/M階段的細(xì)胞周期停滯，延長(zhǎng)腫瘤小鼠的生存時(shí)間，其腫瘤只有對(duì)照組的49%。MCP則對(duì)于腫瘤細(xì)胞和癌癥小鼠效果不明顯。實(shí)驗(yàn)結(jié)果同時(shí)表明，HTCP并不是完全通過(guò)免疫調(diào)節(jié)和GAL-3結(jié)合起作用，而是通過(guò)抑制增生對(duì)腫瘤小鼠產(chǎn)生影響。

Comparative studies on the anti-tumor activities of high temperature- and pH-modified citrus pectins 

Miao Hao, Xiaowen Yuan, Hairong Cheng, Huiting Xue, Tao Zhang, Yifa Zhou and Guihua Tai. 

Food & Function, 2013, 4, 960–971 

Abstract

High temperature and pH modification could produce functional pectins. In this study, high temperaturemodified (HTCP) and pH-modified (MCP) citrus pectins were prepared for studying their anti-tumor activities in eight cancer cell lines and a mouse Sarcoma-180 (S-180) tumor model. HTCP inhibited the proliferation of these cancer cells and induced a caspase-3-dependent cell apoptosis and cell cycle arrest at G2/M phase. It also inhibited the growth of S-180 tumor to 49% of the control at the dose of 200 mg kg-1 –d 1 and extended the survival time of the tumor-bearing mice. MCP had no antiproliferative effects on these cancer cells and no anti-tumor effect in the mouse model. The anti-tumor activity of HTCP in the mouse tumor model was not correlated with immunomodulation and galectin-3 inhibition, but correlated well with proliferation inhibition. HTCP might be exploited as a functional food for cancer prevention and/or treatment.